Environmental factors in the relapse and recurrence of inflammatory bowel disease: A review of the literature

Martin, Thomas D., Chan, Simon S. M. and Hart, Andrew R. (2015) Environmental factors in the relapse and recurrence of inflammatory bowel disease: A review of the literature. Digestive Diseases and Sciences, 60 (5). pp. 1396-1405. ISSN 0163-2116

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Abstract

The causes of relapse in patients with Crohn's disease (CD) and ulcerative colitis (UC) are largely unknown. This paper reviews the epidemiological and clinical data on how medications (non-steroidal anti-inflammatory drugs, estrogens and antibiotics), lifestyle factors (smoking, psychological stress, diet and air pollution) may precipitate clinical relapses and recurrence. Potential biological mechanisms include: increasing thrombotic tendency, imbalances in prostaglandin synthesis, alterations in the composition of gut microbiota, and mucosal damage causing increased permeability.

Item Type:	Article
Uncontrolled Keywords:	relapse,recurrence,inflammatory bowel disease,precipitating factors
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	06 Feb 2015 12:36
Last Modified:	28 Mar 2025 06:26
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52174
DOI:	10.1007/s10620-014-3437-3

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