Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT

Scobie, M., Bew, S.P. and Threadgill, M.D. (1994) Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT. Journal of Labelled Compounds and Radiopharmaceuticals, 34 (9). pp. 881-885. ISSN 0362-4803

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Abstract

Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Social Sciences > School of International Development
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Depositing User: Pure Connector
Date Deposited: 02 Feb 2015 13:48
Last Modified: 21 Apr 2020 23:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/51961
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