Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT

Scobie, M., Bew, S.P. ORCID: https://orcid.org/0000-0002-9087-9463 and Threadgill, M.D. (1994) Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT. Journal of Labelled Compounds and Radiopharmaceuticals, 34 (9). pp. 881-885. ISSN 0362-4803

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Abstract

Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024) Faculty of Social Sciences > School of Global Development (formerly School of International Development)
UEA Research Groups:	Faculty of Science > Research Groups > Chemistry of Materials and Catalysis (former - to 2025)
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	Pure Connector
Date Deposited:	02 Feb 2015 13:48
Last Modified:	18 Jun 2026 16:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/51961
DOI:

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