Scobie, M., Bew, S.P. ORCID: https://orcid.org/0000-0002-9087-9463 and Threadgill, M.D.
(1994)
Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT.
Journal of Labelled Compounds and Radiopharmaceuticals, 34 (9).
pp. 881-885.
ISSN 0362-4803
Abstract
Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.
Item Type: | Article |
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Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
Faculty \ School: | Faculty of Science > School of Chemistry Faculty of Social Sciences > School of International Development |
Related URLs: | |
Depositing User: | Pure Connector |
Date Deposited: | 02 Feb 2015 13:48 |
Last Modified: | 21 Oct 2022 00:29 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/51961 |
DOI: |
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