A thermoresponsive and magnetic colloid for 3D cell expansion and reconfiguration

Saeed, Aram, Francini, Nora, White, Lisa, Dixon, James, Gould, Toby, Rashidi, Hassan, Al Ghanami, Racha Cheikh, Hruschka, Veronika, Redl, Heinz, Saunders, Brian R., Alexander, Cameron and Shakesheff, Kevin M. (2015) A thermoresponsive and magnetic colloid for 3D cell expansion and reconfiguration. Advanced Materials, 27 (4). 662–668. ISSN 0935-9648

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Abstract

A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postculture by the simple process of lowering the temperature and applying an external magnetic field. The colloidal gel can be reconfigured with thermal and magnetic stimuli to allow patterning of cells in discrete zones and to control movement of cells within the porous matrix during culture.

Item Type: Article
Additional Information: © 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: 3d scaffolds,biomaterials,magnetic particles,stem cells,thermoresponsive polymers
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 19 Jan 2015 15:00
Last Modified: 17 Mar 2020 20:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/51774
DOI: 10.1002/adma.201403626

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