Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1

Pchejetski, Dmitri, Foussal, Camille, Alfarano, Chiara, Lairez, Olivier, Calise, Denis, Guilbeau-Frugier, Celine, Schaak, Stéphane, Seguelas, Marie-Hélène, Wanecq, Estelle, Valet, Philippe, Parini, Angelo and Kunduzova, Oksana (2012) Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1. European Heart Journal, 33 (18). pp. 2360-9. ISSN 0195-668X

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Abstract

Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an adipocyte-derived factor, exhibits a number of cardioprotective properties; however, whether apelin is involved in cardiac fibroblast activation and myofibroblast formation remains unknown. The aim of this study was to determine the effects of apelin in activated cardiac fibroblasts, the potential related mechanisms and impact on cardiac fibrotic remodelling process.

Item Type: Article
Uncontrolled Keywords: amp-activated protein kinases,animals,collagen,enzyme inhibitors,fibroblasts,hemodynamics,intercellular signaling peptides and proteins,male,mice,mice, inbred c57bl,myocytes, cardiac,phosphotransferases (alcohol group acceptor),random allocation,transforming growth factor beta,ventricular remodeling
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 16 Dec 2014 10:04
Last Modified: 21 Apr 2020 23:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/51530
DOI: 10.1093/eurheartj/ehr389

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