Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection

Nunes, J, Naymark, M, Sauer, L, Muhammad, A, Keun, H, Sturge, J, Stebbing, J, Waxman, J and Pchejetski, D (2012) Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. British Journal of Cancer, 106 (5). pp. 909-915. ISSN 0007-0920

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Abstract

Current markers available for screening normal populations and for monitoring prostate cancer (PCa) treatment lack sensitivity and selectivity. Sphingosine-1-phosphate (S1P) is a circulating lipid second messenger involved in cell growth and migration, the immune response, angiogenesis, and malignant transformation.

Item Type: Article
Uncontrolled Keywords: anemia,cell line, tumor,disease progression,early detection of cancer,erythrocytes,humans,lysophospholipids,male,phosphotransferases (alcohol group acceptor),prognosis,prostate-specific antigen,prostatic neoplasms,sphingosine,tumor markers, biological
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Environmental Sciences
Depositing User: Pure Connector
Date Deposited: 16 Dec 2014 10:04
Last Modified: 21 Apr 2020 23:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/51529
DOI: 10.1038/bjc.2012.14

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