Re-evaluation of urinary free metadrenalines reference range

Davison, AS, Banks, A, Higgins, G, Pruden, R and Dutton, John (2014) Re-evaluation of urinary free metadrenalines reference range. In: EuroLabFocus, 2014-10-07 - 2014-10-10.

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Diagnosis of phaeochromocytoma can be challenging, current recommendations suggest the measurement of total fractionated urine metadrenalines or plasma free metadrenalines for initial biochemical assessment.1 Few laboratories offer urinary free metadrenalines (UFM) despite them potentially offering greater diagnostic specificity than total fractionated urine metadrenalines. In house urinary free metadrenalines have been available for several years. The rational for perusing this approach is that we believe that the free fraction is the form which is produced directly in the chromaffin cell, though in the chromaffin cell tumour. Therefore it is much more representative than sulphate conjugates which are a product of sulphate transferase 1A3 (SULT1A3) enzyme action in the gastrointestinal tract. The aim of this study was to re-evaluate our current reference ranges in a large local population.

Item Type: Conference or Workshop Item (Poster)
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 19 Nov 2014 12:38
Last Modified: 07 Sep 2021 23:54

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