Urinary excretion of pyridinium crosslinks in healthy 4-10 year olds

Husain, Shahid M., Mughal, Zulf, Williams, Gwen, Ward, Kate, Smith, Colin S., Dutton, John and Fraser, William D. (1999) Urinary excretion of pyridinium crosslinks in healthy 4-10 year olds. Archives of Disease in Childhood, 80 (4). pp. 370-373. ISSN 0003-9888

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Abstract

Urinary pyridinoline and deoxypyridinoline, pyridinium crosslinks released during breakdown of mature collagen, might serve as useful markers of bone resorption. Before their role can be identified, reference values must be established. In this study, free pyridinoline (f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) were measured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decrease in f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, but there was a wide range of values for individuals of similar ages. Further studies are required to assess whether urinary pyridinium crosslink excretion is sufficiently deranged in conditions affecting bone metabolism for the measurement of these compounds to be of clinical value.

Item Type: Article
Uncontrolled Keywords: age factors,amino acids,biological markers,child,child, preschool,collagen,creatinine,female,humans,male,reference values,sex characteristics
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 12 Nov 2014 16:44
Last Modified: 21 Apr 2020 23:35
URI: https://ueaeprints.uea.ac.uk/id/eprint/50901
DOI: 10.1136/adc.80.4.370

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