Development and application of MLVA methods as a tool for inter-laboratory surveillance

Nadon, C A, Trees, E, Ng, L K, Møller Nielsen, E, Reimer, A, Maxwell, N, Kubota, K A, Gerner-Smidt, P, , MLVA Harmonization Working Group and Wain, John (2013) Development and application of MLVA methods as a tool for inter-laboratory surveillance. Eurosurveillance, 18 (35). ISSN 1560-7917

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Abstract

Multiple-locus variable-number of tandem-repeats analysis (MLVA) has emerged as a valuable method for subtyping bacterial pathogens and has been adopted in many countries as a critical component of their laboratory-based surveillance. Lack of harmonisation and standardisation of the method, however, has made comparison of results generated in different laboratories difficult, if not impossible, and has therefore hampered its use in international surveillance. This paper proposes an international consensus on the development, validation, nomenclature and quality control for MLVA used for molecular surveillance and outbreak detection based on a review of the current state of knowledge.

Item Type: Article
Uncontrolled Keywords: clinical laboratory techniques,consensus,consensus development conferences as topic,disease outbreaks,humans,international cooperation,multilocus sequence typing,population surveillance,quality control,tandem repeat sequences
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 12 Nov 2014 16:48
Last Modified: 21 Apr 2020 23:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/50757
DOI:

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