Investigating the link between the presence of enteroaggregative Escherichia coli and infectious intestinal disease in the United Kingdom, 1993 to 1996 and 2008 to 2009

Chattaway, M A, Harris, R, Jenkins, C, Tam, C, Coia, J E, Gray, J, Iturriza-Gomara, M and Wain, J (2013) Investigating the link between the presence of enteroaggregative Escherichia coli and infectious intestinal disease in the United Kingdom, 1993 to 1996 and 2008 to 2009. Eurosurveillance, 18 (37). ISSN 1560-7917

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Abstract

There are an estimated 17 million human diarrhoea cases annually in the United Kingdom. In 2008 and 2009, enteroaggregative E. coli (EAEC) were identified in 1.9% of stools. However, it remains unclear whether there is a causal link between presence of EAEC and disease. This study used bacterial load, the presence of co-infections and demographic data to assess if EAEC was independently associated with intestinal infectious disease. Quantitative real-time PCR data (Ct values) generated directly from stool specimens for several pathogen targets were analysed to identify multiple pathogens, including EAEC, in the stools of cases and healthy controls. Sensitivity and specificity using Ct value (60% and 60%) was not useful for identifying cases or controls, but an independent association between disease and EAEC presence was demonstrated: multivariate logistic regression for EAEC presence (odds ratio: 2.41; 95% confidence interval: 1.78–3.26; p

Item Type: Article
Uncontrolled Keywords: adolescent,adult,aged,case-control studies,coinfection,escherichia coli,escherichia coli infections,feces,female,great britain,humans,incidence,intestinal diseases,logistic models,male,middle aged,multivariate analysis,real-time polymerase chain reaction,young adult
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Social Sciences > School of Education and Lifelong Learning
Depositing User: Pure Connector
Date Deposited: 12 Nov 2014 16:48
Last Modified: 21 Apr 2020 23:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/50756
DOI:

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