Age at migration and risk of first episode psychosis in England:First epidemiological evidence from the SEPEA study

Kirkbride, JB, Hameed, Y, Crane, C, Ankireddipalli, G, Jenkins, O, Kabacs, N, Mestatasio, A, Pandey, S, Ralevic, D, Siddabattuni, S, Walden, B, Zambrana, A, Winton, F, Perez, J, Fowler, D and Jones, PB (2014) Age at migration and risk of first episode psychosis in England:First epidemiological evidence from the SEPEA study. In: World Association of Social Psychiatry Congress (Social Psychiatry: past, present and future), 2014-11-13.

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Aim: To test whether age-at-migration is associated with risk of first episode psychosis [FEP] Background: Although migrant populations experience elevated FEP risk compared with the white British population, it is unclear whether age-at-migration to the UK modifies this risk. Method: Incidence data on all people, aged 16-35 years, presenting with ICD-10 FEP (F10-33) as part of the 3.5-year SEPEA study were obtained. Participants were classified according to age-at-migration (“UK-born, white British”, “UK-born, ethnic minority”, 0-4[infancy], 5-12[childhood], 13-19[adolescence] or 20+ years) and broad ethnic group (non-British white ethnicities; black Caribbean, African & other black ethnicities; Pakistani & Bangladeshi; other Asian ethnicities; other ethnic groups). Poisson regression was used to model FEP incidence by age-at-migration, after adjustment for age and sex, using the 2011 census to estimate person-years at-risk. Results: We identified 664 participants with FEP over 2.02m person-years. Relative to the UK-born white British group, rates were raised amongst first generation black ethnic groups immigrating during infancy (incidence rate ratio [IRR]: 4.6; 95%CI: 2.6-8.4), childhood (IRR: 6.3; 95%CI: 2.8-14.1) and adolescence (IRR: 4.5; 95%CI: 2.3-8.6), with similar trends observed for non-British white (IRR: 2.2; 95%CI: 1.0-4.9; p=0.055) and Pakistani and Bangladeshi groups (IRR: 3.5; 95%CI: 0.9-14.1; p=0.076) immigrating during childhood. Other Asian immigrants, moving to the UK in adulthood, had lower FEP rates (IRR: 0.2; 95%CI: 0.1-0.9). Rates were elevated amongst UK-born ethnic minorities (IRR: 2.7; 95%CI: 2.1-3.5). Conclusion: Our data suggested that moving to the UK during childhood was most strongly associated with increased FEP risk; while migration in adulthood did not confer increased risk, UK-born ethnic minority populations experienced elevated rates.

Item Type: Conference or Workshop Item (Poster)
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 31 Oct 2014 12:58
Last Modified: 26 Feb 2021 01:05

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