Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury

Cubero, Francisco J., Zhao, Gang, Nevzorova, Yulia A., Hatting, Maximilian, Masaoudi, Malika Al, Verdier, Julien, Peng, Jin, Schaefer, Frederik M., Hermanns, Nadine, Boekschoten, Mark V., Grouls, Christoph, Gassler, Nikolaus, Kiessling, Fabian, Muller, Michael, Davis, Roger J., Liedtke, Christian and Trautwein, Christian (2015) Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury. Journal of Hepatology, 62 (1). pp. 140-149. ISSN 0168-8278

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Abstract

Chronic liver injury triggers complications such as liver fibrosis and hepatocellular carcinoma (HCC), which are associated with alterations in distinct signalling pathways. Of particular interest is the interaction between mechanisms controlled by IKKγ/NEMO, the regulatory IKK subunit, and Jnk activation for directing cell death and survival. In the present study, we aimed to define the relevance of Jnk in hepatocyte-specific NEMO knockout mice (NEMOΔhepa), a genetic model of chronic inflammatory liver injury.

Item Type: Article
Uncontrolled Keywords: jnk1,jnk2,necrosis,apoptosis,nemo,hcc
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 08 Oct 2014 08:44
Last Modified: 21 Apr 2020 23:29
URI: https://ueaeprints.uea.ac.uk/id/eprint/50454
DOI: 10.1016/j.jhep.2014.08.029

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