Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling

van der Biezen, Erik A., Sun, Jongho, Coleman, Mark J., Bibb, Mervyn J. and Jones, Jonathan D. G. (2000) Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling. Proceedings of the National Academy of Sciences, 97 (7). pp. 3747-3752. ISSN 0027-8424

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Abstract

Arabidopsis RPP5 is a member of a large class of pathogen resistance genes encoding nucleotide-binding sites and leucine-rich repeat domains. Yeast two-hybrid analysis showed that RPP5 specifically interacts with At-RSH1, an Arabidopsis RelA/SpoT homolog. In Escherichia coli, RelA and SpoT determine the level of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), which are the effector nucleotides of the bacterial stringent response. Functional analysis in E. coli and in Streptomyces coelicolor A3 (2) showed that At-RSH1 confers phenotypes associated with (p)ppGpp synthesis. We characterized two additional Arabidopsis RelA/SpoT homologs, At-RSH2 and At-RSH3. At-RSH genes may regulate a rapid plant (p)ppGpp-mediated response to pathogens and other stresses.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 06 Oct 2014 16:04
Last Modified: 21 Apr 2020 23:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/50324
DOI: 10.1073/pnas.97.7.3747

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