Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomas

Toms, Andoni P, White, Lawrence M, Kandel, Rita, Bleakney, Robert R, Noseworthy, Michael, Shepstone, Lee, Blackstein, Martin E and Wunder, Jay (2009) Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomas. Acta Radiologica, 50 (5). pp. 512-20. ISSN 1600-0455

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Abstract

Single slice dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) appears to provide perfusion data about sarcomas in vivo that correlate with tumor necrosis on equivalent pathological sections. However, sarcomas are heterogeneous and therefore single slice DCE-MRI may not correlate with total tumor necrosis.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,bone neoplasms,capillary permeability,contrast media,female,gadolinium dtpa,humans,image enhancement,image processing, computer-assisted,linear models,magnetic resonance imaging,male,middle aged,necrosis,sarcoma,young adult
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Groups > Statistics
Depositing User:	Pure Connector
Date Deposited:	15 Sep 2014 13:42
Last Modified:	28 Mar 2025 06:10
URI:	https://ueaeprints.uea.ac.uk/id/eprint/50162
DOI:	10.1080/02841850902922761

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