Watts, Richard A, Macgregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325 and Mackie, Sarah L
(2015)
HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis.
Rheumatology, 54 (2).
pp. 359-362.
ISSN 1462-0324
Abstract
Granulomatosis with polyangiitis (GPA) is a rare autoimmune systemic vasculitis considered to result from the interaction of environmental factors with a genetically predisposed host. The HLA-DPB1*0401 allele, the PI*Z allele of the gene encoding α1-antitrypsin (SERPINA1) and the proteinase 3 (PRTN3) gene have been associated with GPA. The incidence of GPA is lower in non-Caucasian populations and has been associated with higher latitude. Our aim was to determine whether variation in population carrier frequency of the HLA-DPB1*0401 and PI*Z alleles could explain in part the variation in GPA incidence between countries.
Item Type: | Article |
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Additional Information: | © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com. |
Uncontrolled Keywords: | granulomatosis with polyangiitis,epidemiology,genetics,hla,vasculitis |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
Depositing User: | Pure Connector |
Date Deposited: | 15 Sep 2014 12:42 |
Last Modified: | 21 Oct 2022 00:07 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/50016 |
DOI: | 10.1093/rheumatology/keu321 |
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