HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis

Watts, Richard A, Macgregor, Alexander and Mackie, Sarah L (2015) HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis. Rheumatology, 54 (2). pp. 359-362. ISSN 1462-0324

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Abstract

Granulomatosis with polyangiitis (GPA) is a rare autoimmune systemic vasculitis considered to result from the interaction of environmental factors with a genetically predisposed host. The HLA-DPB1*0401 allele, the PI*Z allele of the gene encoding α1-antitrypsin (SERPINA1) and the proteinase 3 (PRTN3) gene have been associated with GPA. The incidence of GPA is lower in non-Caucasian populations and has been associated with higher latitude. Our aim was to determine whether variation in population carrier frequency of the HLA-DPB1*0401 and PI*Z alleles could explain in part the variation in GPA incidence between countries.

Item Type:	Article
Additional Information:	© The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Uncontrolled Keywords:	granulomatosis with polyangiitis,epidemiology,genetics,hla,vasculitis
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	Pure Connector
Date Deposited:	15 Sep 2014 12:42
Last Modified:	28 Mar 2025 06:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/50016
DOI:	10.1093/rheumatology/keu321

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