Watts, Richard A, Macgregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325 and Mackie, Sarah L
(2015)
HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis.
Rheumatology, 54 (2).
pp. 359-362.
ISSN 1462-0324
Abstract
Granulomatosis with polyangiitis (GPA) is a rare autoimmune systemic vasculitis considered to result from the interaction of environmental factors with a genetically predisposed host. The HLA-DPB1*0401 allele, the PI*Z allele of the gene encoding α1-antitrypsin (SERPINA1) and the proteinase 3 (PRTN3) gene have been associated with GPA. The incidence of GPA is lower in non-Caucasian populations and has been associated with higher latitude. Our aim was to determine whether variation in population carrier frequency of the HLA-DPB1*0401 and PI*Z alleles could explain in part the variation in GPA incidence between countries.
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