HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis

Watts, Richard A, Macgregor, Alexander and Mackie, Sarah L (2015) HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis. Rheumatology, 54 (2). pp. 359-362. ISSN 1462-0324

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Abstract

Granulomatosis with polyangiitis (GPA) is a rare autoimmune systemic vasculitis considered to result from the interaction of environmental factors with a genetically predisposed host. The HLA-DPB1*0401 allele, the PI*Z allele of the gene encoding α1-antitrypsin (SERPINA1) and the proteinase 3 (PRTN3) gene have been associated with GPA. The incidence of GPA is lower in non-Caucasian populations and has been associated with higher latitude. Our aim was to determine whether variation in population carrier frequency of the HLA-DPB1*0401 and PI*Z alleles could explain in part the variation in GPA incidence between countries.

Item Type: Article
Additional Information: © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Uncontrolled Keywords: granulomatosis with polyangiitis,epidemiology,genetics,hla,vasculitis
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 15 Sep 2014 12:42
Last Modified: 21 Apr 2020 23:23
URI: https://ueaeprints.uea.ac.uk/id/eprint/50016
DOI: 10.1093/rheumatology/keu321

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