Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

Moreno, Estefanía, Andradas, Clara, Medrano, Mireia, Caffarel, María M., Perez-Gomez, Eduardo, Blasco-Benito, Sandra, Gomez-Canas, Maria, Pazos, M. Ruth, Irving, Andrew J., Lluis, Carme, Canela, Enric I., Fernandez-Ruiz, Javier, Guzmán, Manuel, McCormick, P. J. and Sanchez, Cristina (2014) Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling. The Journal of Biological Chemistry, 289 (32). pp. 21960-21972. ISSN 1083-351X

Full text not available from this repository.

Abstract

The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.

Item Type: Article
Uncontrolled Keywords: cancer,cannabinoid,cannabinoid receptor ,g protein-coupled receptor (gpcr) ,signal transduction
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Pure Connector
Date Deposited: 26 Aug 2014 14:52
Last Modified: 11 May 2020 23:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/49978
DOI: 10.1074/jbc.M114.561761

Actions (login required)

View Item View Item