Multiple FLC haplotypes defined by independent cis-regulatory variation underpin life history diversity in Arabidopsis thaliana

Li, Peijin, Filiault, Daniele, Box, Mathew S., Kerdaffrec, Envel, van Oosterhout, Cock, Wilczek, Amity M., Schmitt, Johanna, Mcmullan, Mark, Bergelson, Joy, Nordborg, Magnus and Dean, Caroline (2014) Multiple FLC haplotypes defined by independent cis-regulatory variation underpin life history diversity in Arabidopsis thaliana. Genes & Development, 28 (15). pp. 1635-1640. ISSN 0890-9369

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Abstract

Relating molecular variation to phenotypic diversity is a central goal in evolutionary biology. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) is a major determinant of variation in vernalization—the acceleration of flowering by prolonged cold. Here, through analysis of 1307 A. thaliana accessions, we identify five predominant FLC haplotypes defined by noncoding sequence variation. Genetic and transgenic experiments show that they are functionally distinct, varying in FLC expression level and rate of epigenetic silencing. Allelic heterogeneity at this single locus accounts for a large proportion of natural variation in vernalization that contributes to adaptation of A. thaliana.

Item Type: Article
Additional Information: © 2014 Li et al.; Published by Cold Spring Harbor Laboratory Press This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0.
Uncontrolled Keywords: allelic heterogeneity,flowering locus c,noncoding polymorphism,vernalization,adaptation
Faculty \ School: Faculty of Science > School of Environmental Sciences
Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 15 Aug 2014 15:08
Last Modified: 11 May 2020 23:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/49920
DOI: 10.1101/gad.245993.114

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