Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843 and Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447 (7145). pp. 661-78. ISSN 0028-0836

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Abstract

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approximately 2,000 individuals for each of 7 major diseases and a shared set of approximately 3,000 controls. Case-control comparisons identified 24 independent association signals at P

Item Type:	Article
Uncontrolled Keywords:	arthritis, rheumatoid,bipolar disorder,case-control studies,chromosomes, human,coronary artery disease,crohn disease,diabetes mellitus,gene frequency,genetic markers,genetic predisposition to disease,genetics, population,genome, human,geography,great britain,humans,hypertension,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:36
Last Modified:	03 Nov 2022 15:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49825
DOI:	10.1038/nature05911

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