A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries:a randomised controlled trial

Wong, Samford, Jamous, Ali, O'Driscoll, Jean, Sekhar, Ravi, Weldon, Mike, Yau, Chi Y, Hirani, Shashivadan P, Grimble, George and Forbes, Alastair (2014) A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries:a randomised controlled trial. British Journal of Nutrition, 111 (4). pp. 672-8. ISSN 0007-1145

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Abstract

Certain probiotics may prevent the development of antibiotic-associated diarrhoea (AAD) and Clostridium difficile-associated diarrhoea (CDAD), but their effectiveness depends on both strain and dose. There are few data on nutritional interventions to control AAD/CDAD in the spinal cord injury (SCI) population. The present study aimed to assess (1) the efficacy of consuming a commercially produced probiotic containing at least 6·5 × 10⁹ live Lactobacillus casei Shirota (LcS) in reducing the incidence of AAD/CDAD, and (2) whether undernutrition and proton pump inhibitors (PPI) are risk factors for AAD/CDAD. A total of 164 SCI patients (50·1 (sd 17·8) years) with a requirement for antibiotics (median 21 d, range 5-366) were randomly allocated to receive LcS (n 76) or no probiotic (n 82). LcS was given once daily for the duration of the antibiotic course and continued for 7 days thereafter. Nutritional risk was assessed by the Spinal Nutrition Screening Tool. The LcS group had a significantly lower incidence of AAD (17·1 v. 54·9%, P

Item Type: Article
Uncontrolled Keywords: anti-bacterial agents,appetite,clostridium difficile,diarrhea,double-blind method,energy intake,female,hospitalization,humans,incidence,lactobacillus casei,logistic models,male,malnutrition,meals,middle aged,multivariate analysis,nutritional status,probiotics,proton pump inhibitors,risk factors,spinal cord injuries,treatment outcome
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 05 Aug 2014 16:02
Last Modified: 21 Apr 2020 23:20
URI: https://ueaeprints.uea.ac.uk/id/eprint/49788
DOI: 10.1017/S0007114513002973

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