Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease

Ng, S C, Benjamin, J L, McCarthy, N E, Hedin, C R H, Koutsoumpas, A, Plamondon, S, Price, C L, Hart, A L, Kamm, M A, Forbes, A, Knight, S C, Lindsay, J O, Whelan, K and Stagg, A J (2011) Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease. Inflammatory Bowel Diseases, 17 (10). pp. 2027-2037. ISSN 1078-0998

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Abstract

Altered intestinal dendritic cell (DC) function underlies dysregulated T-cell responses to bacteria in Crohn's disease (CD) but it is unclear whether composition of the intestinal microbiota impacts local DC function. We assessed the relationship between DC function with disease activity and intestinal microbiota in patients with CD.

Item Type: Article
Additional Information: Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.
Uncontrolled Keywords: adult,aged,antigens, cd40,c-reactive protein,case-control studies,crohn disease,dendritic cells,female,flow cytometry,gastrointestinal tract,humans,in situ hybridization, fluorescence,interleukin-10,interleukin-6,intestinal mucosa,male,metagenome,middle aged,toll-like receptor 2,toll-like receptor 4,young adult
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 10:52
Last Modified: 05 May 2020 23:50
URI: https://ueaeprints.uea.ac.uk/id/eprint/49787
DOI: 10.1002/ibd.21590

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