Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease

Koutsoumpas, Andreas, Polymeros, Dimitrios, Tsiamoulos, Zacharias, Smyk, Daniel, Karamanolis, George, Triantafyllou, Konstantinos, Rigopoulou, E I, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843, Vergani, Diego, Bogdanos, Dimitrios P and Ladas, Spiros D (2011) Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease. Journal of Crohn's & Colitis, 5 (2). pp. 101-9. ISSN 1876-4479

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Abstract

We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We also investigated whether peptide-recognition is due to Cx37/microbial molecular mimicry.

Item Type:	Article
Additional Information:	Copyright © 2010 Elsevier B.V. All rights reserved.
Uncontrolled Keywords:	adult,antigen-antibody reactions,bacterial proteins,connexins,crohn disease,enterovirus b, human,enterovirus c, human,female,humans,lactococcus lactis,male,middle aged,molecular mimicry,sequence homology, amino acid,viral proteins,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:50
Last Modified:	21 Oct 2022 00:02
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49784
DOI:	10.1016/j.crohns.2010.10.009

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