IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

Tremelling, Mark, Cummings, Fraser, Fisher, Sheila A, Mansfield, John, Gwilliam, Rhian, Keniry, Andrew, Nimmo, Elaine R, Drummond, Hazel, Onnie, Clive M, Prescott, Natalie J, Sanderson, Jeremy, Bredin, Francesca, Berzuini, Carlo, Forbes, Alastair, Lewis, Cathryn M, Cardon, Lon, Deloukas, Panos, Jewell, Derek, Mathew, Christopher G, Parkes, Miles and Satsangi, Jack (2007) IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology, 132 (5). pp. 1657-64. ISSN 0016-5085

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Abstract

Identification of inflammatory bowel disease (IBD) susceptibility genes is key to understanding pathogenic mechanisms. Recently, the North American IBD Genetics Consortium provided compelling evidence for an association between ileal Crohn's disease (CD) and the IL23R gene using genome-wide association scanning. External replication is a priority, both to confirm this finding in other populations and to validate this new technique. We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15.

Item Type: Article
Uncontrolled Keywords: adult,case-control studies,cohort studies,colitis, ulcerative,crohn disease,england,epistasis, genetic,female,genetic predisposition to disease,humans,inflammatory bowel diseases,male,nod2 signaling adaptor protein,phenotype,polymorphism, single nucleotide,receptors, interleukin,risk factors,scotland
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 10:58
Last Modified: 21 Apr 2020 23:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/49676
DOI: 10.1053/j.gastro.2007.02.051

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