Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease

Lindsay, J O, Whelan, K, Stagg, A J, Gobin, P, Al-Hassi, H O, Rayment, N, Kamm, M A, Knight, S C and Forbes, A (2006) Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease. Gut, 55 (3). pp. 348-355. ISSN 0017-5749

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Abstract

The intestinal microbiota play a pivotal role in the inflammation associated with Crohn's disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL-10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease.

Item Type: Article
Uncontrolled Keywords: adult,bifidobacterium,crohn disease,dendritic cells,feces,female,humans,immunity, mucosal,intestinal mucosa,male,middle aged,oligosaccharides,patient compliance,severity of illness index,toll-like receptors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 10:50
Last Modified: 30 Apr 2020 23:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/49643
DOI: 10.1136/gut.2005.074971

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