Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease

Colombel, J F, Rutgeerts, P, Malchow, H, Jacyna, M, Nielsen, O H, Rask-Madsen, J, Van Deventer, S, Ferguson, A, Desreumaux, P, Forbes, A ORCID: https://orcid.org/0000-0001-7416-9843, Geboes, K, Melani, L and Cohard, M (2001) Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease. Gut, 49 (1). pp. 42-46. ISSN 0017-5749

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Abstract

New lesions of Crohn's disease occur early after ileal or ileocolonic resection and ileocolonic anastomosis. We performed a double blind controlled trial to evaluate the safety and tolerance of recombinant human interleukin 10 (IL-10; Tenovil) in subjects operated on for Crohn's disease. We also assessed the effect of Tenovil in preventing endoscopic recurrence 12 weeks after surgery.

Item Type:	Article
Uncontrolled Keywords:	adult,chemotherapy, adjuvant,colonoscopy,crohn disease,double-blind method,electrophoresis, agar gel,female,hematocrit,hemoglobins,humans,interleukin-1,interleukin-10,intestinal mucosa,male,patient compliance,recurrence,reverse transcriptase polymerase chain reaction,statistics, nonparametric,treatment outcome,tumor necrosis factor-alpha,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:38
Last Modified:	18 Jun 2026 16:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49575
DOI:	10.1136/gut.49.1.42

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