Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis

Thomas, M G, Nugent, K P, Forbes, A ORCID: and Williamson, R C (1994) Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis. Gut, 35 (12). pp. 1718-1720. ISSN 0017-5749

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Vitamin D3 reduces human rectal crypt cell production rate (CCPR) and may thereby protect against colorectal cancer. Cell turnover is increased in ulcerative proctocolitis, which might therefore respond to vitamin D3 metabolites. This study investigated the effect of calcipotriol, a synthetic vitamin D3 analogue that avoids hypercalcaemia, on human rectal CCPR in ulcerative proctocolitis. Paired rectal biopsy specimens from seven patients with severe disease were established in organ culture with or without calcipotriol (1 x 10(-6) M). After 15 hours, vincristine (0.6 microgram/ml) was added to induce metaphase arrest, and CCPR was determined by linear regression analysis of accumulated metaphases. Compared with values in 17 controls with incidental anal conditions, median rectal CCPR was 28% higher in ulcerative proctocolitis: 5.90 (5.00-9.50) v 4.80 (2.85-7.07) cells/crypt/hour (p

Item Type: Article
Uncontrolled Keywords: adult,aged,aged, 80 and over,calcitriol,cell division,colitis, ulcerative,colorectal neoplasms,depression, chemical,epithelium,female,humans,male,middle aged,organ culture techniques,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 10:56
Last Modified: 20 Oct 2022 23:58
DOI: 10.1136/gut.35.12.1718

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