Low Back and Common Widespread Pain Share Common Genetic Determinants

Malkin, Ida, Williams, Frances M K, LaChance, Genevieve, Spector, Timothy, Macgregor, Alexander and Livshits, Gregory (2014) Low Back and Common Widespread Pain Share Common Genetic Determinants. Annals of Human Genetics, 78 (5). 357–366. ISSN 0003-4800

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Abstract

Low back (LBP) and chronic widespread musculoskeletal pain (CWP) both have a significant genetic component and are associated with increased body mass index (BMI). We examined whether LBP and CWP share common genetic factors, and to what extent this correlation is modified by the genetic factors influencing BMI. Genetic analysis of binary traits such as pain is not simple, particularly if their risk is associated with age or other quantitative traits. Implementing Falconer's polygenic threshold concept for dichotomous traits inheritance, we developed new software to examine the extent of the genetic influence on LBP and CWP under age and BMI dependence. The analysis was conducted on 3266 and 2256 UK female twins, assessed for LBP and CWP, respectively. Analysis of the liability scores with threshold to LBP and CWP established substantial contribution of genetic factors to their variation (h(2) > 0.60, p

Item Type: Article
Additional Information: © 2014 John Wiley & Sons Ltd/University College London.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 05 Aug 2014 15:56
Last Modified: 21 Apr 2020 23:14
URI: https://ueaeprints.uea.ac.uk/id/eprint/49335
DOI: 10.1111/ahg.12074

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