Studies on iron availability in man, using stable isotope techniques

Fairweather-Tait, S J ORCID: and Minski, M J (1986) Studies on iron availability in man, using stable isotope techniques. British Journal of Nutrition, 55 (2). pp. 279-85. ISSN 0007-1145

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1. Iron absorption from 10 mg Fe (as ferrous sulphate), labelled with 1.3 mg 58Fe, was measured in fasting, non-anaemic adult subjects by the faecal-balance technique. The measurement was performed twice, each subject being given, in random order, either 50 mg Fe or a placebo 18 h before the 58Fe-labelled FeSO4. 2. The 50 mg Fe load significantly reduced Fe absorption the following day (P less than 0.01), from a mean of 35.4 (SEM 4.6)% to 29.0 (SEM 5.1)%. This points to the importance of strict dietary control during Fe-absorption studies to eliminate bias in results. 3. In a separate study, the feasibility of using 58Fe-enrichment of erythrocytes, measured by neutron activation analysis (NAA), 10 d after a meal labelled with 0.69 mg 58Fe as an index of Fe absorption was examined. The levels of 58Fe in the blood were detectable by NAA. Regression analysis showed a significant relation between 58Fe-enrichment of blood and 58Fe absorption, calculated as the difference between intake and faecal excretion (R 0.59, P less than 0.05).

Item Type: Article
Uncontrolled Keywords: absorption,adolescent,adult,biological availability,erythrocytes,feces,female,hemoglobins,humans,iron,iron isotopes,male,middle aged,neutron activation analysis
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 10:42
Last Modified: 24 Oct 2022 06:33

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