Lactoferrin and iron absorption in newborn infants

Fairweather-Tait, Susan J. ORCID:, Balmer, Susan E., Scott, Paul H. and Minski, Margaret J. (1987) Lactoferrin and iron absorption in newborn infants. Pediatric Research, 22 (6). pp. 651-654. ISSN 0031-3998

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Results from experiments in this laboratory using 59Fe suggest that bovine lactoferrin (Lf) has no effect on iron absorption in rats. A study was therefore carried out in newborn infants to measure the effects of Lf on iron retention. Bovine Lf was labeled with the stable isotope 58Fe and fed to 7-day-old infants in a standard milk formula. Iron retention was estimated by measuring the unabsorbed 58Fe excreted in the feces during the following 3 days using neutron activation analysis. The results were compared with those obtained from a group of infants fed a similar level of iron as ferric chloride, labeled with 58Fe, together with 30 mg ascorbic acid. There was a very wide variation in percent iron retention amongst the infants but no overall difference between the Lf and ferric chloride groups. This confirms the previous findings in rats that Lf does not influence the availability of nonheme iron.

Item Type: Article
Uncontrolled Keywords: absorption,biological availability,chlorides,female,ferric compounds,humans,infant, newborn,iron,iron isotopes,lactoferrin,lactoglobulins,male
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 05 Aug 2014 12:56
Last Modified: 24 Oct 2022 06:33
DOI: 10.1203/00006450-198712000-00007

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