Riboflavin deficiency in the rat: Effects on iron utilization and loss

Powers, Hilary J., Weaver, L. T., Austin, S., Wright, A. J. A. and Fairweather-Tait, S. J. ORCID: https://orcid.org/0000-0002-1413-5569 (1991) Riboflavin deficiency in the rat: Effects on iron utilization and loss. British Journal of Nutrition, 65 (3). pp. 487-496. ISSN 0007-1145

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Iron absorption and daily loss of Fe were measured in riboflavin-deficient (B2-) Norwegian hooded rats and controls (B2+). Animals were fed on a test meal extrinsically labelled with 59Fe and whole-body radioactivity measured for 15 d. Riboflavin deficiency led to a reduction in the percentage of the 59Fe dose absorbed and an increased rate of 59Fe loss. All post-absorption 59Fe loss could be accounted for by faecal 59Fe, confirming that the loss was gastrointestinal. Fe concentrations and 59Fe as a percentage of retained whole-body 59Fe were higher in the small intestine of riboflavin-deficient animals than their controls, 14 d after the test meal. A separate experiment demonstrated that riboflavin deficiency was associated with a significant proliferative response of the duodenal crypts of the small intestine. These observations may explain the enhanced Fe loss in riboflavin deficiency.

Item Type: Article
Uncontrolled Keywords: absorption,animals,body weight,duodenum,female,intestine, small,iron,iron radioisotopes,liver,rats,riboflavin deficiency,tissue distribution
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 05 Aug 2014 12:50
Last Modified: 24 Oct 2022 06:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/49236
DOI: 10.1079/BJN19910107

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