Rare earth elements as nonabsorbable fecal markers in studies of iron absorption

Fairweather-Tait, S J ORCID: https://orcid.org/0000-0002-1413-5569, Minihane, A M ORCID: https://orcid.org/0000-0001-9042-4226, Eagles, J, Owen, L and Crews, H M (1997) Rare earth elements as nonabsorbable fecal markers in studies of iron absorption. American Journal of Clinical Nutrition, 65 (4). pp. 970-976. ISSN 0002-9165

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The use of rare earth elements as nonabsorbable fecal markers for studies of iron absorption from sources labeled extrinsically with stable isotopes was evaluated. On 3 successive days 13 healthy fasting adults were given different stable isotopes of iron with samarium, ytterbium, or dysprosium. On day 1, three meals were given with 57Fe (1 mg per meal) plus samarium (0.33 mg per meal); on day 2, identical meals (taken with a calcium supplement to reduce iron bioavailability) were given with equivalent amounts of 58Fe-labeled iron and ytterbium; on day 3, a well-absorbed reference dose of 54Fe (3 mg) was given with 1 mg Dy. A complete fecal collection was carried out for 5-9 d and each stool was analyzed for rare earth elements by inductively coupled plasma-mass spectrometry and iron isotopes by thermal ionization quadrupole mass spectrometry. Mean recovery of rare earth elements was 101%, indicating that they are totally unabsorbed. The excretory pattern of the iron isotopes and the rare earth elements was very similar; the correlation coefficients between samarium and 57Fe, ytterbium and 58Fe, and dysprosium and 54Fe were 0.992, 0.989, and 0.988, respectively (P

Item Type: Article
Uncontrolled Keywords: absorption,adult,aged,biological markers,dose-response relationship, drug,dysprosium,feces,female,gas chromatography-mass spectrometry,humans,iron,iron isotopes,male,middle aged,samarium,ytterbium
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 05 Aug 2014 12:28
Last Modified: 24 Oct 2022 06:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/49205

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