Zinc metabolism in non-insulin dependent diabetes mellitus

Rauscher, A M, Fairweather-Tait, S J ORCID: https://orcid.org/0000-0002-1413-5569, Wilson, P D, Gorrick, S and Greenwood, R (1997) Zinc metabolism in non-insulin dependent diabetes mellitus. Journal of Trace Elements in Medicine and Biology, 11 (2). pp. 65-70. ISSN 0946-672X

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Low plasma zinc concentrations and increased zinc excretion have been reported in patients with non-insulin dependent diabetes mellitus (NIDDM). This study was designed to compare zinc metabolism in ten NIDDM patients with ten healthy controls, using stable isotopes of zinc. Zinc absorption from a standard breakfast labelled extrinsically with 3 mg 67Zn was measured using a fecal monitoring technique and thermal ionization quadrupole mass spectrometry. One hour after the test meal each volunteer was given 0.5 mg 70Zn (as citrate) intravenously and blood samples taken at intervals for up to 6 days. Isotopic enrichment was measured and the data entered into a simple kinetic model to estimate the size and rate of turnover of exchangeable pools of zinc. Urinary zinc excretion was higher in the male diabetics than controls (p

Item Type: Article
Uncontrolled Keywords: aged,diabetes mellitus, type 2,diet,female,humans,male,middle aged,models, biological,zinc,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 21 Jul 2014 15:56
Last Modified: 24 Oct 2022 06:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/49204
DOI: 10.1016/S0946-672X(97)80028-4

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