Use of the stable isotope (106)Cd for studying dietary cadmium absorption in humans

Crews, Helen M., Owen, Linda M., Langford, Nicola, Fairweather-Tait, Susan J. ORCID:, Fox, Tom E., Hubbard, Lisa and Phillips, Diane (2000) Use of the stable isotope (106)Cd for studying dietary cadmium absorption in humans. Toxicology Letters, 112-113. pp. 201-207. ISSN 0378-4274

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Hydroponically grown wheat was intrinsically labelled with the stable isotope 106cadmium (106Cd) and the flour made into a porridge. The abundance of the isotope in the porridge was approximately 30 times the natural abundance, but the total level of Cd in the porridge was 0.03 mg/kg fresh weight, which was the same as expected in a normal diet. Cadmium measurements were made using inductively coupled plasma-mass spectrometry (ICP-MS). The porridge was eaten at breakfast by adult and infant volunteers. Bulked faecal collections were analysed for unabsorbed Cd. Initial results suggest that the apparent absorption of Cd may be higher than 5% as commonly quoted, but longer faecal collection times may be necessary to confirm this.

Item Type: Article
Uncontrolled Keywords: adult,cadmium,cereals,diet,feces,female,humans,infant,intestinal absorption,isotopes,mass spectrometry,middle aged
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Chemistry
Faculty of Social Sciences > School of Education and Lifelong Learning
Depositing User: Pure Connector
Date Deposited: 25 Jul 2014 12:36
Last Modified: 24 Oct 2022 06:31
DOI: 10.1016/S0378-4274(99)00284-2

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