Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins

Butt, Julea (2014) Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins. Biochemical Society Transactions, 42. pp. 47-51. ISSN 0300-5127

Full text not available from this repository. (Request a copy)

Abstract

Apoptosis is triggered by an accumulation of ROS (reactive oxygen species) produced by proteins of the mitochondrial respiratory chain. The levels of ROS are controlled by the activities of mitochondrial redox proteins such as glutaredoxin 2 that help to modulate the susceptibility of a cell to apoptosis. However, once downstream events have resulted in the release of cytochrome c to the cytosol, it is widely considered that cell death is inevitable. Cytochrome c may promote its own release from mitochondria through interactions with the mitochondrial phospholipid cardiolipin (diphosphatidylglycerol). In the present article, spectroelectrochemistry of the cardiolipin complex of cytochrome c and protein film electrochemistry of glutaredoxin 2 are reviewed to illustrate how electrochemical methods provide insight into the properties of signalling proteins.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 09 Jul 2014 09:46
Last Modified: 21 Apr 2020 23:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/49037
DOI: 10.1042/BST20130256

Actions (login required)

View Item View Item