Confocal laser endomicroscopy in gastrointestinal diseases

Goetz, Martin, Watson, Alastair ORCID: and Kiesslich, Ralf (2011) Confocal laser endomicroscopy in gastrointestinal diseases. Journal of Biophotonics, 4 (7-8). pp. 498-508. ISSN 1864-0648

[thumbnail of J_Biophotonics_2011_Confocal Laser Endomicroscopy for GI diseases_final] Microsoft Word (J_Biophotonics_2011_Confocal Laser Endomicroscopy for GI diseases_final) - Draft Version
Download (3MB)


Confocal laser endomicroscopy (CLE) is a novel endoscopic technique permitting in vivo microscopy (optical biopsies) of the gastrointestinal mucosa. CLE has been studied in a multitude of diseases of the upper and lower gastrointestinal tract, including Barrett's esophagus, gastric inflammation and cancer, celiac disease, colorectal adenoma and carcinoma, and inflammatory bowel diseases. CLE has recently evolved and been studied for bile duct and liver imaging. CLE has shown overall high accuracy and enabled smart, targeted biopsies rather than untargeted sampling. Furthermore, the availability of real time microscopic information during endoscopy has immediate impact on therapeutic decisions and guides endoscopic interventions. CLE is also a unique tool for observation of (patho-)physiologic events in their natural environment (functional imaging) and has been linked to molecular imaging of gastrointestinal neoplasia in vivo, thereby broadening our understanding of mucosal pathology in clinical and basic science.

Item Type: Article
Additional Information: Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Uncontrolled Keywords: animals,endoscopy, gastrointestinal,gastrointestinal diseases,humans,lasers,lower gastrointestinal tract,microscopy, confocal,staining and labeling,upper gastrointestinal tract,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 07 Jul 2014 14:00
Last Modified: 23 Dec 2022 02:33
DOI: 10.1002/jbio.201100022

Actions (login required)

View Item View Item