Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: An approach to methylidenefluorenes

Zhu, Daqian, Wu, Yongcheng, Wu, Baojian, Luo, Bingling, Ganesan, A., Wu, Fu-hai, Pi, Rongbiao, Huang, Peng and Wen, Shijun (2014) Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: An approach to methylidenefluorenes. Organic Letters, 16 (9). pp. 2350-2353. ISSN 1523-7060

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Abstract

Linear diaryliodonium salts are widely used as arylating reagents for C–C and C–X bond formation. Meanwhile, synthetic applications of cyclic iodoniums are relatively rare although they offer the opportunity to set up reaction cascades. We demonstrate an atom and step economical three-component reaction involving cyclic diphenyleneiodoniums, alkynes, and boronic acids, resulting in the construction of methylidenefluorenes in a single operation. Our route enables facile access to both symmetrical and unsymmetrical methylidenefluorene derivatives, compounds that have attracted interest due to their optical properties.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Pure Connector
Date Deposited:	11 Jun 2014 12:58
Last Modified:	14 Jul 2025 23:45
URI:	https://ueaeprints.uea.ac.uk/id/eprint/48560
DOI:	10.1021/ol5006714

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