The X-ray crystal structure of Shewanella oneidensis OmcA reveals new insight at the microbe-mineral interface

Edwards, Marcus J, Baiden, Nanakow, Johs, Alexander, Tomanicek, Stephen J, Liang, Liyuan, Shi, Liang, Fredrickson, Jim K, Zachara, John M, Gates, Andrew J, Butt, Julea N, Richardson, David J and Clarke, Thomas A (2014) The X-ray crystal structure of Shewanella oneidensis OmcA reveals new insight at the microbe-mineral interface. FEBS Letters, 588 (10). pp. 1886-1890. ISSN 0014-5793

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Abstract

The X-ray crystal structure of Shewanella oneidensis OmcA, an extracellular decaheme cytochrome involved in mineral reduction, was solved to a resolution of 2.7 Å. The four OmcA molecules in the asymmetric unit are arranged so the minimum distance between heme 5 on adjacent OmcA monomers is 9 Å, indicative of a transient OmcA dimer capable of intermolecular electron transfer. A previously identified hematite binding motif was identified near heme 10, forming a hydroxylated surface that would bring a heme 10 electron egress site to ∼ 10 Å of a mineral surface.

Item Type: Article
Additional Information: Copyright © 2014. Published by Elsevier B.V.
Uncontrolled Keywords: multiheme cytochrome,mineral respiration,electron transfer,shewanella,c-type heme,outer membrane,metalloprotein
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science
Faculty of Science > School of Chemistry
Depositing User: Pure Connector
Date Deposited: 12 May 2014 15:34
Last Modified: 12 Sep 2019 15:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/48431
DOI: 10.1016/j.febslet.2014.04.013

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