Brown and white adipose tissues. Intrinsic differences in gene expression and response to cold exposure in mice

Rosell, Meritxell, Kaforou, Myrsini, Frontini, Andrea, Okolo, Anthony, Chan, Yi-Wah, Nikolopoulou, Evanthia, Millership, Steven, Fenech, Matthew E., MacIntyre, David, Turner, Jeremy O., Moore, Jonathan D., Blackburn, Edith, Gullick, William J., Cinti, Saverio, Montana, Giovanni, Parker, Malcolm G. and Christian, Mark (2014) Brown and white adipose tissues. Intrinsic differences in gene expression and response to cold exposure in mice. American Journal of Physiology - Endocrinology and Metabolism, 306 (8). ISSN 1522-1555

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Brown adipocytes dissipate energy whereas white adipocytes are an energy storage site. We explored the plasticity of different white adipose tissue depots in acquiring a brown phenotype by cold exposure. By comparing cold-induced genes in white fat to those enriched in brown compared to white fat, at thermoneutrality, we defined a "BRITE" transcription signature. We identified the genes, pathways and promoter regulatory motifs associated with "browning" as these represent novel targets for understanding this process. For example, Neuregulin 4 was more highly expressed in brown adipose tissue, upregulated in white fat upon cold exposure and cell studies showed it is a neurite outgrowth-promoting adipokine, indicative of a role in increasing adipose tissue innervation in response to cold. A cell culture system that allows us to reproduce the differential properties of the discrete adipose depots was developed to study depot specific differences at an in vitro level. The key transcriptional events underpinning white adipose tissue to brown transition are important as they represent an attractive proposition to overcome the detrimental effects associated with metabolic disorders including obesity and Type 2 diabetes.

Item Type: Article
Uncontrolled Keywords: adipose,brown fat, adipokine,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User: Pure Connector
Date Deposited: 30 May 2014 19:56
Last Modified: 31 Oct 2023 01:43
DOI: 10.1152/ajpendo.00473.2013

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