Synthesis of Novel Calix[4]arene Based Dendrimers and their Biological Applications

Atzori, Simone (2013) Synthesis of Novel Calix[4]arene Based Dendrimers and their Biological Applications. Doctoral thesis, University of East Anglia.

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This thesis describes the development and synthesis of multicalixarenes and their
application in gene and drug delivery.
Chapter 1 provides an introduction to gene therapy and calixarenes. The synthesis of two
families of amino functionalised multicalixarenes are described. Evaluation of their toxicity
and transfection studies are reported and a number of candidates for development identified.
Chapter 2 describes the development of calixarene glycoconjugates using a wide range of
approaches. The synthesis of calixarene glycoconjugates through click chemistry is
reported and the development of the first multicalixarene glycoconjugate is discussed.
Chapter 3 reviews the development of large multicalixarenes assemblies. The synthesis of
large (9 and 21 member) click based multicalixarenes is described.

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Users 2259 not found.
Date Deposited: 11 Mar 2014 16:02
Last Modified: 11 Mar 2014 16:02


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