Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis

Beraza, Naiara, Ofner-Ziegenfuss, Lisa, Ehedego, Haksier, Boekschoten, Mark, Bischoff, Stephan C, Muller, Michael, Trauner, Michael and Trautwein, Christian (2011) Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis. Gut, 60 (3). pp. 387-396. ISSN 0017-5749

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Abstract

Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.

Item Type: Article
Uncontrolled Keywords: animals,anti-inflammatory agents, non-steroidal,apoptosis,cell proliferation,diet, fat-restricted,disease progression,down-regulation,drug evaluation, preclinical,fatty liver,hepatocytes,intracellular signaling peptides and proteins,lipids,liver,liver cirrhosis,mice,mice, knockout,oligonucleotide array sequence analysis,ursodeoxycholic acid
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 10 Jun 2014 20:42
Last Modified: 21 Apr 2020 22:53
URI: https://ueaeprints.uea.ac.uk/id/eprint/47751
DOI: 10.1136/gut.2010.223834

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