Beraza, Naiara, Ofner-Ziegenfuss, Lisa, Ehedego, Haksier, Boekschoten, Mark, Bischoff, Stephan C, Muller, Michael ORCID: https://orcid.org/0000-0002-5930-9905, Trauner, Michael and Trautwein, Christian
(2011)
Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis.
Gut, 60 (3).
pp. 387-396.
ISSN 0017-5749
Abstract
Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | animals,anti-inflammatory agents, non-steroidal,apoptosis,cell proliferation,diet, fat-restricted,disease progression,down-regulation,drug evaluation, preclinical,fatty liver,hepatocytes,intracellular signaling peptides and proteins,lipids,liver,liver cirrhosis,mice,mice, knockout,oligonucleotide array sequence analysis,ursodeoxycholic acid |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology |
Depositing User: | Pure Connector |
Date Deposited: | 10 Jun 2014 20:42 |
Last Modified: | 24 Oct 2022 06:09 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/47751 |
DOI: | 10.1136/gut.2010.223834 |
Actions (login required)
![]() |
View Item |