Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis

Beraza, Naiara, Ofner-Ziegenfuss, Lisa, Ehedego, Haksier, Boekschoten, Mark, Bischoff, Stephan C, Muller, Michael ORCID: https://orcid.org/0000-0002-5930-9905, Trauner, Michael and Trautwein, Christian (2011) Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis. Gut, 60 (3). pp. 387-396. ISSN 0017-5749

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Abstract

Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice.

Item Type:	Article
Uncontrolled Keywords:	animals,anti-inflammatory agents, non-steroidal,apoptosis,cell proliferation,diet, fat-restricted,disease progression,down-regulation,drug evaluation, preclinical,fatty liver,hepatocytes,intracellular signaling peptides and proteins,lipids,liver,liver cirrhosis,mice,mice, knockout,oligonucleotide array sequence analysis,ursodeoxycholic acid
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Pure Connector
Date Deposited:	10 Jun 2014 20:42
Last Modified:	24 Oct 2022 06:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47751
DOI:	10.1136/gut.2010.223834

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