Stress- (and diet-) related regulation of hepatic nuclear receptors and its relevance for ABC-transporter functions

Stienstra, Rinke, Lichtenauer-Kaligis, Elgin and Müller, Michael ORCID: (2004) Stress- (and diet-) related regulation of hepatic nuclear receptors and its relevance for ABC-transporter functions. Drug Metabolism Reviews, 36 (2). pp. 391-406. ISSN 0360-2532

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Nuclear receptors (NRs) play an important role in maintaining cellular homeostasis. With clearly established roles in fatty acid metabolism and inflammation, peroxisome proliferator activated receptors (PPARs) and other nuclear receptors are essential in liver functioning. However, much less is known about the regulation of NRs themselves during inflammatory processes in the liver. Interestingly PPARs and other NRs are negative acute phase proteins because they become rapidly downregulated during the acute phase response. However, PPARs have important roles in modulating inflammatory responses. One of the mechanisms by which dietary or inflammatory stress is relieved involves the hepatic adenosine triphosphate-binding cassette (ABC) transporter proteins, which import and export a wide variety of substrates. These ABC transporters are under close control of several NRs. Because NRs play important roles in fatty acid metabolism and inflammation as well as in the regulation of bile production, they are reviewed here with respect to their role in dietary and stress-related responses of the liver and their impact on the regulation and function of hepatic ABC transporters.

Item Type: Article
Uncontrolled Keywords: atp-binding cassette transporters,acute-phase reaction,animals,diet,hepatitis,humans,liver,liver cirrhosis,peroxisome proliferator-activated receptors,receptors, cytoplasmic and nuclear,stress, physiological,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 07 Jul 2014 12:04
Last Modified: 24 Oct 2022 06:08
DOI: 10.1081/DMR-120037573

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