Nutrigenomics:the impact of biomics technology on nutrition research

Corthésy-Theulaz, Irène, den Dunnen, Johan T, Ferré, Pascal, Geurts, Jan M W, Müller, Michael ORCID:, van Belzen, Nico and van Ommen, Ben (2005) Nutrigenomics:the impact of biomics technology on nutrition research. Annals of Nutrition & Metabolism, 49 (6). pp. 355-65. ISSN 0250-6807

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The interaction between the human body and nutrition is an extremely complex process involving multi-organ physiology with molecular mechanisms on all levels of regulation (genes, gene expression, proteins, metabolites). Only with the recent technology push have nutritional scientists been able to address this complexity. Both the challenges and promises that are offered by the merge of 'biomics' technologies and mechanistic nutrition research are huge, but will eventually evolve in a new nutrition research concept: nutritional systems biology. This review describes the principles and technologies involved in this merge. Using nutrition research examples, including gene expression modulation by carbohydrates and fatty acids, this review discusses applications as well as limitations of genomics, transcriptomics, proteomics, metabolomics, and systems biology. Furthermore, reference is made to gene polymorphisms that underlie individual differences in nutrient utilization, resulting in, e.g., different susceptibility to develop obesity.

Item Type: Article
Uncontrolled Keywords: biotechnology,energy metabolism,gene expression regulation,genome, human,genomics,humans,nutritional physiological phenomena,polymorphism, genetic,proteomics,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Pure Connector
Date Deposited: 07 Jul 2014 12:06
Last Modified: 24 Oct 2022 06:08
DOI: 10.1159/000088315

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