Nutrigenomics:from molecular nutrition to prevention of disease

Afman, Lydia and Müller, Michael (2006) Nutrigenomics:from molecular nutrition to prevention of disease. Journal of the American Dietetic Association, 106 (4). pp. 569-76. ISSN 0002-8223

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Abstract

Until recently, nutrition research concentrated on nutrient deficiencies and impairment of health. The advent of genomics-interpreted broadly as a suite of high throughput technologies for the generation, processing, and application of scientific information about the composition and functions of genomes-has created unprecedented opportunities for increasing our understanding of how nutrients modulate gene and protein expression and ultimately influence cellular and organismal metabolism. Nutritional genomics (nutrigenomics), the junction between health, diet, and genomics, can be seen as the combination of molecular nutrition and genomics. The diverse tissue and organ-specific effects of bioactive dietary components include gene-expression patterns (transcriptome); organization of the chromatin (epigenome); protein-expression patterns, including posttranslational modifications (proteome); as well as metabolite profiles (metabolome). Nutrigenomics will promote an increased understanding of how nutrition influences metabolic pathways and homeostatic control, how this regulation is disturbed in the early phases of diet-related disease, and the extent to which individual sensitizing genotypes contribute to such diseases. Eventually, nutrigenomics will lead to evidence-based dietary intervention strategies for restoring health and fitness and for preventing diet-related disease. In this review, we provide a brief overview of nutrigenomics from our point of view by describing current strategies, future opportunities, and challenges.

Item Type: Article
Uncontrolled Keywords: chronic disease,diet,gene expression regulation,genomics,humans,microarray analysis,nutritional physiological phenomena,primary prevention,public health
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 07 Jul 2014 12:06
Last Modified: 14 Sep 2020 07:04
URI: https://ueaeprints.uea.ac.uk/id/eprint/47732
DOI: 10.1016/j.jada.2006.01.001

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