Conjugated linoleic acid enhances transepithelial calcium transport in human intestinal-like Caco-2 cells:an insight into molecular changes

Murphy, Eileen F, Jewell, Christopher, Hooiveld, Guido J, Muller, Michael and Cashman, Kevin D (2006) Conjugated linoleic acid enhances transepithelial calcium transport in human intestinal-like Caco-2 cells:an insight into molecular changes. Prostaglandins, Leukotrienes and Essential Fatty Acids, 74 (5). pp. 295-301. ISSN 0952-3278

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Abstract

Conjugated linoleic acid (CLA) has been shown to enhance paracellular and transcellular Ca transport across human intestinal-like Caco-2 cell monolayers. The mechanisms of action, however, are still unclear. Therefore, this study investigated the molecular mechanisms underlying CLA-induced stimulation of Ca transport by use of preliminary microarray data together with more detailed and comprehensive quantitative reverse transcriptase-PCR analysis. While molecular expression of junctional adhesion molecule (JAM), ZO-2, ZO-3, claudin 2 and claudin 3 were unaltered, ZO-1, occludin, and claudin 4 were all up-regulated (1.6, 1.6, 2.4-fold, respectively; P

Item Type: Article
Uncontrolled Keywords: biological transport,caco-2 cells,calcium,calcium channels,cell membrane permeability,claudin-1,claudin-4,gene expression,humans,intestinal mucosa,linoleic acids, conjugated,membrane proteins,occludin,oligonucleotide array sequence analysis,tight junctions
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 03 Mar 2014 18:10
Last Modified: 21 Apr 2020 22:53
URI: https://ueaeprints.uea.ac.uk/id/eprint/47731
DOI: 10.1016/j.plefa.2006.03.003

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