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Murphy, Eileen F, Jewell, Christopher, Hooiveld, Guido J, Muller, Michael 
ORCID: https://orcid.org/0000-0002-5930-9905 and Cashman, Kevin D
(2006)
Conjugated linoleic acid enhances transepithelial calcium transport in human intestinal-like Caco-2 cells:an insight into molecular changes.
Prostaglandins, Leukotrienes and Essential Fatty Acids, 74 (5).
pp. 295-301.
ISSN 0952-3278
Abstract
Conjugated linoleic acid (CLA) has been shown to enhance paracellular and transcellular Ca transport across human intestinal-like Caco-2 cell monolayers. The mechanisms of action, however, are still unclear. Therefore, this study investigated the molecular mechanisms underlying CLA-induced stimulation of Ca transport by use of preliminary microarray data together with more detailed and comprehensive quantitative reverse transcriptase-PCR analysis. While molecular expression of junctional adhesion molecule (JAM), ZO-2, ZO-3, claudin 2 and claudin 3 were unaltered, ZO-1, occludin, and claudin 4 were all up-regulated (1.6, 1.6, 2.4-fold, respectively; P
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | biological transport,caco-2 cells,calcium,calcium channels,cell membrane permeability,claudin-1,claudin-4,gene expression,humans,intestinal mucosa,linoleic acids, conjugated,membrane proteins,occludin,oligonucleotide array sequence analysis,tight junctions |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology |
| Depositing User: | Pure Connector |
| Date Deposited: | 03 Mar 2014 18:10 |
| Last Modified: | 24 Oct 2022 06:08 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/47731 |
| DOI: | 10.1016/j.plefa.2006.03.003 |
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