The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver

Stienstra, Rinke, Mandard, Stéphane, Tan, Nguan Soon, Wahli, Walter, Trautwein, Christian, Richardson, Terrilyn A, Lichtenauer-Kaligis, Elgin, Kersten, Sander and Müller, Michael (2007) The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Journal of Hepatology, 46 (5). pp. 869-77. ISSN 0168-8278

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Abstract

The Peroxisome Proliferator-Activated Receptor (PPAR) alpha belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes. The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver.

Item Type: Article
Uncontrolled Keywords: animals,anticholesteremic agents,carcinoma, hepatocellular,female,gene expression regulation,hepatitis,hepatocytes,humans,hypoglycemic agents,interleukin 1 receptor antagonist protein,liver,male,mice,mice, knockout,ppar alpha,promoter regions, genetic,pyrimidines,rna, messenger,receptors, interleukin-1 type i,thiazolidinediones,transcription factors,transcription, genetic,transcriptional activation,tumor cells, cultured,up-regulation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 07 Jul 2014 12:02
Last Modified: 21 Apr 2020 22:53
URI: https://ueaeprints.uea.ac.uk/id/eprint/47721
DOI: 10.1016/j.jhep.2006.11.019

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