Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation:functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells

Bouwens, Mark, Afman, Lydia A and Müller, Michael (2007) Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation:functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells. American Journal of Clinical Nutrition, 86 (5). pp. 1515-23. ISSN 0002-9165

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Abstract

Peripheral blood mononuclear cells (PBMCs) are the only readily available cells in healthy humans. Various studies showed disease-characteristic gene expression patterns in PBMCs. However, little is known of nutritional effects on PBMC gene expression patterns. Fatty acids are nutrients that regulate gene expression by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). PBMCs express PPARalpha, making these cells interesting to study FA-dependent gene expression.

Item Type: Article
Uncontrolled Keywords: adult,cells, cultured,fasting,fatty acids,fatty acids, nonesterified,gene expression profiling,humans,leukocytes, mononuclear,male,oligonucleotide array sequence analysis,oxidation-reduction,ppar alpha,polymerase chain reaction
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 07 Jul 2014 12:02
Last Modified: 21 Apr 2020 22:53
URI: https://ueaeprints.uea.ac.uk/id/eprint/47717
DOI:

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