Effect of synthetic dietary triglycerides:a novel research paradigm for nutrigenomics

Sanderson, Linda M, de Groot, Philip J, Hooiveld, Guido J E J, Koppen, Arjen, Kalkhoven, Eric, Müller, Michael and Kersten, Sander (2008) Effect of synthetic dietary triglycerides:a novel research paradigm for nutrigenomics. PLoS One, 3 (2). ISSN 1932-6203

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The effect of dietary fats on human health and disease are likely mediated by changes in gene expression. Several transcription factors have been shown to respond to fatty acids, including SREBP-1c, NF-kappaB, RXRs, LXRs, FXR, HNF4alpha, and PPARs. However, it is unclear to what extent these transcription factors play a role in gene regulation by dietary fatty acids in vivo.

Item Type: Article
Additional Information: © 2008 Sanderson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords: animals,cells, cultured,dietary fats,gene expression profiling,gene expression regulation,liver,ppar alpha,rats,structure-activity relationship,transcription factors,triglycerides
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 10 Jun 2014 21:50
Last Modified: 14 Sep 2020 07:04
URI: https://ueaeprints.uea.ac.uk/id/eprint/47715
DOI: 10.1371/journal.pone.0001681

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