Giebeler, Arne, Boekschoten, Mark V, Klein, Christian, Borowiak, Malgorzata, Birchmeier, Carmen, Gassler, Nikolaus, Wasmuth, Hermann E, Müller, Michael, Trautwein, Christian and Streetz, Konrad L (2009) c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice. Gastroenterology, 137 (1). pp. 297-308. ISSN 0016-5085

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Abstract

The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been shown in acute liver regeneration, its cell-specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined.

Item Type:	Article
Uncontrolled Keywords:	animals,apoptosis,cell proliferation,cholestasis, extrahepatic,chronic disease,common bile duct,cytokines,disease models, animal,disease progression,extracellular matrix proteins,gene expression profiling,hepatic stellate cells,hepatitis,hepatocyte growth factor,hepatocytes,inflammation mediators,ligation,liver,liver cirrhosis,mice,mice, knockout,necrosis,neutrophil infiltration,oligonucleotide array sequence analysis,proto-oncogene proteins c-met,time factors
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Pure Connector
Date Deposited:	21 Feb 2014 11:58
Last Modified:	21 Apr 2020 22:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47703
DOI:	10.1053/j.gastro.2009.01.068

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