Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Rakhshandehroo, Maryam, Hooiveld, Guido, Müller, Michael and Kersten, Sander (2009) Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One, 4 (8). ISSN 1932-6203

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Abstract

Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver. Here we set out to compare the function of PPARalpha in mouse and human hepatocytes via analysis of target gene regulation.

Item Type: Article
Uncontrolled Keywords: animals,gene expression regulation,hepatocytes,humans,lipid metabolism,mice,ppar alpha,peroxisome proliferators,pyrimidines,species specificity
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 21 Feb 2014 12:00
Last Modified: 21 Apr 2020 22:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/47698
DOI: 10.1371/journal.pone.0006796

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