Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study

Lu, Yingchang, Feskens, Edith Jm, Dollé, Martijn Et, Imholz, Sandra, Verschuren, Wm Monique, Müller, Michael and Boer, Jolanda Ma (2010) Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study. American Journal of Clinical Nutrition, 92 (1). pp. 258-265. ISSN 0002-9165

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Abstract

The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies.

Item Type: Article
Uncontrolled Keywords: 3' untranslated regions,apolipoproteins b,cholesterol,cholesterol, dietary,cholesterol, hdl,cohort studies,fatty acid desaturases,genetic variation,genome, human,genotype,humans,multigene family,netherlands,polymorphism, single nucleotide
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 10 Jun 2014 20:48
Last Modified: 21 Apr 2020 22:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/47683
DOI: 10.3945/ajcn.2009.29130

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