Literature-based genetic risk scores for coronary heart disease:the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study

Vaarhorst, Anika A M, Lu, Yingchang, Heijmans, Bastiaan T, Dollé, Martijn E T, Böhringer, Stefan, Putter, Hein, Imholz, Sandra, Merry, Audrey H H, van Greevenbroek, Marleen M, Jukema, J Wouter, Gorgels, Anton P M, van den Brandt, Piet A, Müller, Michael, Schouten, Leo J, Feskens, Edith J M, Boer, Jolanda M A and Slagboom, P Eline (2012) Literature-based genetic risk scores for coronary heart disease:the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study. Circulation: Cardiovascular Genetics, 5 (2). pp. 202-209. ISSN 1942-3268

Full text not available from this repository. (Request a copy)

Abstract

Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD.

Item Type: Article
Uncontrolled Keywords: adult,cardiovascular diseases,female,follow-up studies,genome-wide association study,genotype,humans,male,middle aged,polymorphism, single nucleotide,prospective studies,registries,risk factors,young adult
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 10 Jun 2014 20:34
Last Modified: 21 Apr 2020 22:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/47658
DOI: 10.1161/CIRCGENETICS.111.960708

Actions (login required)

View Item View Item