TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis

Lu, Yingchang, Boer, Jolanda M. A., Barsova, Roza M., Favorova, Olga, Goel, Anuj, Müller, Michael ORCID: and Feskens, Edith J M and PROCARDIS CARDIoGRAM Consortium (2012) TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis. BMC Medical Genetics, 13. ISSN 1471-2350

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Background: Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent. Methods: We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed. Results: Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs1800471, and 4 studies involving 5143 cases and 4229 controls for rs1800472. The pooled odds ratios (ORs) for CHD among minor T allele carriers of rs1800469, minor C allele carriers of rs1982073, and minor C allele carriers of rs1800471 versus homozygous major allele carriers was 1.14 (95% confidence interval [CI]: 1.05-1.24), 1.18 (95% CI: 1.04-1.35), and 1.16 (95% CI: 1.02-1.32), respectively. No substantial heterogeneity for ORs was detected among the included Caucasian populations for all SNPs. However, for rs1800471, the statistical significance disappeared after adjusting for potential publication bias. No significant association was found between rs1800468 and rs1800472 variants and CHD risk. Conclusion: Minor allele carriers of two genetic variants (rs1800469 and rs1982073) in TGFB1 have a 15% increased risk of CHD.

Item Type: Article
Uncontrolled Keywords: coronary disease,european continental ancestry group,female,gene frequency,genetic predisposition to disease,genetic variation,humans,male,polymorphism, single nucleotide,risk,transforming growth factor beta1
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Pure Connector
Date Deposited: 10 Jun 2014 20:42
Last Modified: 03 Nov 2022 15:36
DOI: 10.1186/1471-2350-13-39

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